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At the request of Bishop Peter Kenrick, a group of Sisters left Kaskaskia and opened a school for girls on Sixth Street near Olive in St. Louis. Only two months later, in June, the remaining Kaskaskia community was forced by the flooded Mississippi to abandon their new brick school building and move to St. Louis. This group then conducted a school in a large home on Broadway, lent to them by Mrs. Ann Biddle. By 1846, both communities and schools were reunited in a building on Ninth Street, on the corner of Menard and Marion Streets. A charter from the state of Missouri was secured in 1855.
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